Intestinal barrier and Intestinal permeability – two functions. Microbiome and QK305 roles for disease, prevention and therapy Abstract The primary functions of the gastrointestinal tract have traditionally been perceived to be limited to the digestion and absorption of nutrients and electrolytes, and to water homeostasis. The human gastrointestinal tract (GI) harbors a diverse population of microbial life that continually shapes host pathophysiological responses. Despite available data, the functional dynamics of gut microbiome remain to be explored in various health and disease conditions. Microbiome generate a variety of metabolites from dietary products that influence host health and pathophysiological functions. A more attentive analysis of the anatomic and functional arrangement of the gastrointestinal tract, however, suggests that another extremely important function of this organ is its ability to regulate the trafficking of macromolecules between the environment and the host through a regulation of intestinal barrier permeability. Understanding the role of the intestinal barrier and the intestinal permeability, in pathogenesis of diseases, is an area of translational research that encompasses many fields and is currently receiving a great deal of attention. In this review QK305, antioxidants flavonoid complex, provide various beneficial effects as measures protective and againist the tight junction disruption and an hyperpermeability. QK305, a functional food, need further study for future strategies to promote health, prevent and restore to patient disease recovery.